Cargando…

mTOR-Dependent Autophagy Regulates Slit Diaphragm Density in Podocyte-like Drosophila Nephrocytes

Both mTOR signaling and autophagy are important modulators of podocyte homeostasis, regeneration, and aging and have been implicated in glomerular diseases. However, the mechanistic role of these pathways for the glomerular filtration barrier remains poorly understood. We used Drosophila nephrocytes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Spitz, Dominik, Comas, Maria, Gerstner, Lea, Kayser, Séverine, Helmstädter, Martin, Walz, Gerd, Hermle, Tobias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265458/ https://www.ncbi.nlm.nih.gov/pubmed/35805186 http://dx.doi.org/10.3390/cells11132103

Ejemplares similares

Selective endocytosis controls slit diaphragm maintenance and dynamics in Drosophila nephrocytes
por: Lang, Konrad, et al.
Publicado: (2022)

Using the Drosophila Nephrocyte to Model Podocyte Function and Disease
por: Helmstädter, Martin, et al.
Publicado: (2017)

Using Drosophila Nephrocytes to Understand the Formation and Maintenance of the Podocyte Slit Diaphragm
por: van de Leemput, Joyce, et al.
Publicado: (2022)

The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm
por: Weavers, Helen, et al.
Publicado: (2008)

Apical-basal polarity regulators are essential for slit diaphragm assembly and endocytosis in Drosophila nephrocytes
por: Heiden, Stefanie, et al.
Publicado: (2021)

PI(4,5)P2 controls slit diaphragm formation and endocytosis in Drosophila nephrocytes
por: Gass, Maximilian M., et al.
Publicado: (2022)

Endocytosis mediated by an atypical CUBAM complex modulates slit diaphragm dynamics in nephrocytes
por: Atienza-Manuel, Alexandra, et al.
Publicado: (2021)

An acytokinetic cell division creates PIP2-enriched membrane asymmetries leading to slit diaphragm assembly in Drosophila nephrocytes
por: Carrasco-Rando, Marta, et al.
Publicado: (2023)

Endocytic Trafficking at the Mature Podocyte Slit Diaphragm
por: Swiatecka-Urban, Agnieszka
Publicado: (2017)

Hypoxia decreases podocyte expression of slit diaphragm proteins
por: Lu, Hong, et al.
Publicado: (2012)

Networks that link cytoskeletal regulators and diaphragm proteins underpin filtration function in Drosophila nephrocytes
por: Muraleedharan, Simi, et al.
Publicado: (2018)

Slit diaphragm maintenance requires dynamic clathrin-mediated endocytosis facilitated by AP-2, Lap, Aux and Hsc70-4 in nephrocytes
por: Wang, Luyao, et al.
Publicado: (2021)

Proteinuric Kidney Diseases: A Podocyte's Slit Diaphragm and Cytoskeleton Approach
por: Yu, Samuel Mon-Wei, et al.
Publicado: (2018)

New insight into podocyte slit diaphragm, a therapeutic target of proteinuria
por: Kawachi, Hiroshi, et al.
Publicado: (2020)

IQGAP1 Interacts with Components of the Slit Diaphragm Complex in Podocytes and Is Involved in Podocyte Migration and Permeability In Vitro
por: Rigothier, Claire, et al.
Publicado: (2012)

Rabphilin involvement in filtration and molecular uptake in Drosophila nephrocytes suggests a similar role in human podocytes
por: Selma-Soriano, Estela, et al.
Publicado: (2020)

CRIM1 is localized to the podocyte filtration slit diaphragm of the adult human kidney
por: Nyström, Jenny, et al.
Publicado: (2009)

Nephrin Signaling in the Podocyte: An Updated View of Signal Regulation at the Slit Diaphragm and Beyond
por: Martin, Claire E., et al.
Publicado: (2018)

WWC1 promotes podocyte survival via stabilizing slit diaphragm protein dendrin
por: Lin, Ting, et al.
Publicado: (2017)

An Essential Role of the Universal Polarity Protein, aPKCλ, on the Maintenance of Podocyte Slit Diaphragms
por: Hirose, Tomonori, et al.
Publicado: (2009)

Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes
por: Ivy, Jessica R., et al.
Publicado: (2015)

Phosphorylation of slit diaphragm proteins NEPHRIN and NEPH1 upon binding of HGF promotes podocyte repair
por: Solanki, Ashish K., et al.
Publicado: (2021)

Modeling of ACTN4-Based Podocytopathy Using Drosophila Nephrocytes
por: Odenthal, Johanna, et al.
Publicado: (2022)

MAGI-1 Interacts with Nephrin to Maintain Slit Diaphragm Structure through Enhanced Rap1 Activation in Podocytes
por: Ni, Jie, et al.
Publicado: (2016)

Role of calcineurin (CN) in kidney glomerular podocyte: CN inhibitor ameliorated proteinuria by inhibiting the redistribution of CN at the slit diaphragm
por: Wakamatsu, Ayako, et al.
Publicado: (2016)

A slit-diaphragm-associated protein network for dynamic control of renal filtration
por: Kocylowski, Maciej K., et al.
Publicado: (2022)

Organoids from Nephrotic Disease-Derived iPSCs Identify Impaired NEPHRIN Localization and Slit Diaphragm Formation in Kidney Podocytes
por: Tanigawa, Shunsuke, et al.
Publicado: (2018)

Sodium hydrogen sulfide (NaHS) ameliorates alterations caused by cisplatin in filtration slit diaphragm and podocyte cytoskeletal in rat kidney
por: Karimi, Asiyeh, et al.
Publicado: (2017)

Rabphilin silencing causes dilated cardiomyopathy in a Drosophila model of nephrocyte damage
por: Selma-Soriano, Estela, et al.
Publicado: (2021)

A protective role for Drosophila Filamin in nephrocytes via Yorkie mediated hypertrophy
por: Koehler, Sybille, et al.
Publicado: (2022)

Interaction of the sorting nexin 25 homologue Snazarus with Rab11 balances endocytic and secretory transport and maintains the ultrafiltration diaphragm in nephrocytes
por: Maruzs, Tamás, et al.
Publicado: (2023)

POROUS SUBSTRUCTURE OF THE GLOMERULAR SLIT DIAPHRAGM IN THE RAT AND MOUSE
por: Rodewald, Richard, et al.
Publicado: (1974)

New perspectives on the renal slit diaphragm protein podocin
por: Relle, Manfred, et al.
Publicado: (2011)

dCubilin- or dAMN-mediated protein reabsorption in Drosophila nephrocytes modulates longevity
por: Feng, Xiaoming, et al.
Publicado: (2021)

A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes
por: Lee, Jin-Gu, et al.
Publicado: (2023)

Identification of Bipotential Blood Cell/Nephrocyte Progenitors in Drosophila: Another Route for Generating Blood Progenitors
por: Morin-Poulard, Ismaël, et al.
Publicado: (2022)

Nephrocytes are part of the spectrum of filtration epithelial diversity
por: Miyaki, Takayuki, et al.
Publicado: (2020)

Evolutionary conservation of intrinsically unstructured regions in slit-diaphragm proteins
por: Mulukala, Sandeep K. N., et al.
Publicado: (2021)

Role of mTOR signaling in the regulation of high glucose-induced podocyte injury
por: Li, Qiuyue, et al.
Publicado: (2019)

Substructure of the glomerular slit diaphragm in freeze-fractured normal rat kidney
por: Karnovsky, MJ, et al.
Publicado: (1975)

Cannot write session to /tmp/vufind_sessions/sess_mfftf7hkvjgs92h058a696ufo5