Increased Resection at DSBs in G(2)-Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ

The load of DNA double-strand breaks (DSBs) induced in the genome of higher eukaryotes by different doses of ionizing radiation (IR) is a key determinant of DSB repair pathway choice, with homologous recombination (HR) and ATR substantially gaining ground at doses below 0.5 Gy. Increased resection a...

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Detalles Bibliográficos
Autores principales: Xiao, Huaping, Li, Fanghua, Mladenov, Emil, Soni, Aashish, Mladenova, Veronika, Pan, Bing, Dueva, Rositsa, Stuschke, Martin, Timmermann, Beate, Iliakis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265841/
https://www.ncbi.nlm.nih.gov/pubmed/35805183
http://dx.doi.org/10.3390/cells11132099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265841/
https://www.ncbi.nlm.nih.gov/pubmed/35805183
http://dx.doi.org/10.3390/cells11132099

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