CaMKII Inhibition Attenuates Distinct Gain-of-Function Effects Produced by Mutant Nav1.6 Channels and Reduces Neuronal Excitability

Aberrant Nav1.6 activity can induce hyperexcitability associated with epilepsy. Gain-of-function mutations in the SCN8A gene encoding Nav1.6 are linked to epilepsy development; however, the molecular mechanisms mediating these changes are remarkably heterogeneous and may involve post-translational r...

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Detalles Bibliográficos
Autores principales: Zybura, Agnes S., Sahoo, Firoj K., Hudmon, Andy, Cummins, Theodore R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266207/
https://www.ncbi.nlm.nih.gov/pubmed/35805192
http://dx.doi.org/10.3390/cells11132108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266207/
https://www.ncbi.nlm.nih.gov/pubmed/35805192
http://dx.doi.org/10.3390/cells11132108

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