Relaxin Inhibits the Cardiac Myofibroblast NLRP3 Inflammasome as Part of Its Anti-Fibrotic Actions via the Angiotensin Type 2 and ATP (P2X7) Receptors

Chronic NLRP3 inflammasome activation can promote fibrosis through its production of interleukin (IL)-1β and IL-18. Conversely, recombinant human relaxin (RLX) can inhibit the pro-fibrotic interactions between IL-1β, IL-18 and transforming growth factor (TGF)-β1. Here, the broader extent by which RL...

Descripción completa

Detalles Bibliográficos
Autores principales: Tapia Cáceres, Felipe, Gaspari, Tracey A., Hossain, Mohammed Akhter, Samuel, Chrishan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266307/
https://www.ncbi.nlm.nih.gov/pubmed/35806076
http://dx.doi.org/10.3390/ijms23137074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266307/
https://www.ncbi.nlm.nih.gov/pubmed/35806076
http://dx.doi.org/10.3390/ijms23137074

Ejemplares similares