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Relaxin Inhibits the Cardiac Myofibroblast NLRP3 Inflammasome as Part of Its Anti-Fibrotic Actions via the Angiotensin Type 2 and ATP (P2X7) Receptors

Chronic NLRP3 inflammasome activation can promote fibrosis through its production of interleukin (IL)-1β and IL-18. Conversely, recombinant human relaxin (RLX) can inhibit the pro-fibrotic interactions between IL-1β, IL-18 and transforming growth factor (TGF)-β1. Here, the broader extent by which RL...

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Detalles Bibliográficos
Autores principales:	Tapia Cáceres, Felipe, Gaspari, Tracey A., Hossain, Mohammed Akhter, Samuel, Chrishan S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266307/ https://www.ncbi.nlm.nih.gov/pubmed/35806076 http://dx.doi.org/10.3390/ijms23137074

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