Probing the Conformational States of Thimet Oligopeptidase in Solution

Thimet oligopeptidase (TOP) is a metallopeptidase involved in the metabolism of oligopeptides inside and outside cells of various tissues. It has been proposed that substrate or inhibitor binding in the TOP active site induces a large hinge-bending movement leading to a closed structure, in which th...

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Detalles Bibliográficos
Autores principales: Marcondes, Marcelo F. M., Santos, Gabriel S., Bronze, Fellipe, Machado, Mauricio F. M., Perez, Kátia R., Hesselink, Renske, de Vries, Marcel P., Broos, Jaap, Oliveira, Vitor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266445/
https://www.ncbi.nlm.nih.gov/pubmed/35806299
http://dx.doi.org/10.3390/ijms23137297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266445/
https://www.ncbi.nlm.nih.gov/pubmed/35806299
http://dx.doi.org/10.3390/ijms23137297

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