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Probing the Conformational States of Thimet Oligopeptidase in Solution

Thimet oligopeptidase (TOP) is a metallopeptidase involved in the metabolism of oligopeptides inside and outside cells of various tissues. It has been proposed that substrate or inhibitor binding in the TOP active site induces a large hinge-bending movement leading to a closed structure, in which th...

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Detalles Bibliográficos
Autores principales:	Marcondes, Marcelo F. M., Santos, Gabriel S., Bronze, Fellipe, Machado, Mauricio F. M., Perez, Kátia R., Hesselink, Renske, de Vries, Marcel P., Broos, Jaap, Oliveira, Vitor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266445/ https://www.ncbi.nlm.nih.gov/pubmed/35806299 http://dx.doi.org/10.3390/ijms23137297

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