Activation of the eIF2α-ATF4 Pathway by Chronic Paracetamol Treatment Is Prevented by Dietary Supplementation with Cysteine

Chronic treatment with acetaminophen (APAP) induces cysteine (Cys) and glutathione (GSH) deficiency which leads to adverse metabolic effects including muscle atrophy. Mammalian cells respond to essential amino acid deprivation through the phosphorylation of the eukaryotic translation initiation fact...

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Detalles Bibliográficos
Autores principales: Carraro, Valérie, Combaret, Lydie, Coudy-Gandilhon, Cécile, Parry, Laurent, Averous, Julien, Maurin, Anne-Catherine, Jousse, Céline, Voyard, Guillaume, Fafournoux, Pierre, Papet, Isabelle, Bruhat, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266523/
https://www.ncbi.nlm.nih.gov/pubmed/35806203
http://dx.doi.org/10.3390/ijms23137196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266523/
https://www.ncbi.nlm.nih.gov/pubmed/35806203
http://dx.doi.org/10.3390/ijms23137196

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