Characterization of Pyrrolidinyl-hexahydro-pyranopiperazines as a Novel Kappa Opioid Receptor Agonist Scaffold

[Image: see text] The kappa agonist structure–activity relationship around the novel, pyrrolidinyl substituted pyranopiperazine scaffold was developed. More specifically, the dichloroPhenylAcetamide-Pyrrolidinyl-PyranoPiperazine (PAPPP) core A was the focus of our work. The modulation of kappa recep...

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Detalles Bibliográficos
Autores principales: Reed, Brian, Miller, Michael, Michino, Mayako, Butelman, Eduardo R., Ben-Ezra, Ariel, Pikus, Philip, Morochnik, Michelle, Kim, Yuli, Ripka, Amy, Vacca, Joseph, Kreek, Mary Jeanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266631/
https://www.ncbi.nlm.nih.gov/pubmed/35738565
http://dx.doi.org/10.1021/acschemneuro.2c00258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266631/
https://www.ncbi.nlm.nih.gov/pubmed/35738565
http://dx.doi.org/10.1021/acschemneuro.2c00258

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