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Characterization of Pyrrolidinyl-hexahydro-pyranopiperazines as a Novel Kappa Opioid Receptor Agonist Scaffold
[Image: see text] The kappa agonist structure–activity relationship around the novel, pyrrolidinyl substituted pyranopiperazine scaffold was developed. More specifically, the dichloroPhenylAcetamide-Pyrrolidinyl-PyranoPiperazine (PAPPP) core A was the focus of our work. The modulation of kappa recep...
Autores principales: | Reed, Brian, Miller, Michael, Michino, Mayako, Butelman, Eduardo R., Ben-Ezra, Ariel, Pikus, Philip, Morochnik, Michelle, Kim, Yuli, Ripka, Amy, Vacca, Joseph, Kreek, Mary Jeanne |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266631/ https://www.ncbi.nlm.nih.gov/pubmed/35738565 http://dx.doi.org/10.1021/acschemneuro.2c00258 |
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