Seventy-Two-Hour LRRK2 Kinase Activity Inhibition Increases Lysosomal GBA Expression in H4, a Human Neuroglioma Cell Line

Mutations in LRRK2 and GBA1 are key contributors to genetic risk of developing Parkinson’s disease (PD). To investigate how LRRK2 kinase activity interacts with GBA and contributes to lysosomal dysfunctions associated with the pathology of PD. The activity of the lysosomal enzyme β-Glucocerebrosidas...

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Detalles Bibliográficos
Autores principales: Ruz, Clara, Alcantud, José Luis, Vives, Francisco, Arrebola, Francisco, Hardy, John, Lewis, Patrick A., Manzoni, Claudia, Duran, Raquel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266636/
https://www.ncbi.nlm.nih.gov/pubmed/35805938
http://dx.doi.org/10.3390/ijms23136935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266636/
https://www.ncbi.nlm.nih.gov/pubmed/35805938
http://dx.doi.org/10.3390/ijms23136935

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