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Seventy-Two-Hour LRRK2 Kinase Activity Inhibition Increases Lysosomal GBA Expression in H4, a Human Neuroglioma Cell Line
Mutations in LRRK2 and GBA1 are key contributors to genetic risk of developing Parkinson’s disease (PD). To investigate how LRRK2 kinase activity interacts with GBA and contributes to lysosomal dysfunctions associated with the pathology of PD. The activity of the lysosomal enzyme β-Glucocerebrosidas...
Autores principales: | Ruz, Clara, Alcantud, José Luis, Vives, Francisco, Arrebola, Francisco, Hardy, John, Lewis, Patrick A., Manzoni, Claudia, Duran, Raquel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266636/ https://www.ncbi.nlm.nih.gov/pubmed/35805938 http://dx.doi.org/10.3390/ijms23136935 |
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