Surface cysteine to serine substitutions in IL-18 reduce aggregation and enhance activity

BACKGROUND: Interleukin-18 (IL-18) is prone to form multimers resulting in inactive aggregates, making this cytokine unstable for clinical use. Therefore, mutations have been introduced into recombinant IL-18 to overcome this issue. METHODS: To prevent the formation of disulfide bonds between the IL...

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Detalles Bibliográficos
Autores principales: Saetang, Jirakrit, Roongsawang, Niran, Sangkhathat, Surasak, Voravuthikunchai, Supayang Piyawan, Sangkaew, Natnaree, Prompat, Napat, Srichana, Teerapol, Tipmanee, Varomyalin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2022
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266699/
https://www.ncbi.nlm.nih.gov/pubmed/35811828
http://dx.doi.org/10.7717/peerj.13626

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266699/
https://www.ncbi.nlm.nih.gov/pubmed/35811828
http://dx.doi.org/10.7717/peerj.13626

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