CDK1 Promotes Epithelial–Mesenchymal Transition and Migration of Head and Neck Squamous Carcinoma Cells by Repressing ∆Np63α-Mediated Transcriptional Regulation

∆Np63α is a key transcription factor overexpressed in types of squamous cell carcinomas (SCCs), which represses epithelial–mesenchymal transition (EMT) and cell migration. In this study, we found that CDK1 phosphorylates ∆Np63α at the T123 site, impairing its affinity to the target promoters of its...

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Detalles Bibliográficos
Autores principales: Chen, Huimin, Hu, Ke, Xie, Ying, Qi, Yucheng, Li, Wenjuan, He, Yaohui, Fan, Shijie, Liu, Wen, Li, Chenghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266818/
https://www.ncbi.nlm.nih.gov/pubmed/35806389
http://dx.doi.org/10.3390/ijms23137385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266818/
https://www.ncbi.nlm.nih.gov/pubmed/35806389
http://dx.doi.org/10.3390/ijms23137385

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