Metabolic Reprogramming in Sickle Cell Diseases: Pathophysiology and Drug Discovery Opportunities

Sickle cell disease (SCD) is a genetic disorder that affects millions of individuals worldwide. Chronic anemia, hemolysis, and vasculopathy are associated with SCD, and their role has been well characterized. These symptoms stem from hemoglobin (Hb) polymerization, which is the primary event in the...

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Detalles Bibliográficos
Autores principales: Alramadhani, Dina, Aljahdali, Anfal S., Abdulmalik, Osheiza, Pierce, B. Daniel, Safo, Martin K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266828/
https://www.ncbi.nlm.nih.gov/pubmed/35806451
http://dx.doi.org/10.3390/ijms23137448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266828/
https://www.ncbi.nlm.nih.gov/pubmed/35806451
http://dx.doi.org/10.3390/ijms23137448

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