Protective antibodies elicited by SARS-CoV-2 spike protein vaccination are boosted in the lung after challenge in nonhuman primates

Adjuvanted soluble protein vaccines have been used extensively in humans for protection against various viral infections based on their robust induction of antibody responses. Here, soluble prefusion-stabilized spike protein trimers (preS dTM) from severe acute respiratory syndrome coronavirus 2 (SA...

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Detalles Bibliográficos
Autores principales: Francica, Joseph R., Flynn, Barbara J., Foulds, Kathryn E., Noe, Amy T., Werner, Anne P., Moore, Ian N., Gagne, Matthew, Johnston, Timothy S., Tucker, Courtney, Davis, Rachel L., Flach, Britta, O’Connell, Sarah, Andrew, Shayne F., Lamb, Evan, Flebbe, Dillon R., Nurmukhambetova, Saule T., Donaldson, Mitzi M., Todd, John-Paul M., Zhu, Alex Lee, Atyeo, Caroline, Fischinger, Stephanie, Gorman, Matthew J, Shin, Sally, Edara, Venkata Viswanadh, Floyd, Katharine, Lai, Lilin, Boyoglu-Barnum, Seyhan, Van De Wetering, Renee, Tylor, Alida, McCarthy, Elizabeth, Lecouturier, Valerie, Ruiz, Sophie, Berry, Catherine, Tibbitts, Timothy, Andersen, Hanne, Cook, Anthony, Dodson, Alan, Pessaint, Laurent, Van Ry, Alex, Koutsoukos, Marguerite, Gutzeit, Cindy, Teng, I.-Ting, Zhou, Tongqing, Li, Dapeng, Haynes, Barton F., Kwong, Peter D., McDermott, Adrian, Lewis, Mark G., Fu, Tong Ming, Chicz, Roman, van der Most, Robbert, Corbett, Kizzmekia S., Suthar, Mehul S., Alter, Galit, Roederer, Mario, Sullivan, Nancy J., Douek, Daniel C., Graham, Barney S., Casimiro, Danilo, Seder, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266840/
https://www.ncbi.nlm.nih.gov/pubmed/34315825
http://dx.doi.org/10.1126/scitranslmed.abi4547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266840/
https://www.ncbi.nlm.nih.gov/pubmed/34315825
http://dx.doi.org/10.1126/scitranslmed.abi4547

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