Immunomodulatory Properties of PI3K/AKT/mTOR and MAPK/MEK/ERK Inhibition Augment Response to Immune Checkpoint Blockade in Melanoma and Triple-Negative Breast Cancer

Hyperactivation of PI3K/AKT/mTOR and MAPK/MEK/ERK signaling pathways is commonly observed in many cancers, including triple-negative breast cancer (TNBC) and melanoma. Moreover, the compensatory upregulation of the MAPK/MEK/ERK pathway has been associated with therapeutic resistance to targeted inhi...

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Detalles Bibliográficos
Autores principales: Zhang, Zhizhu, Richmond, Ann, Yan, Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266842/
https://www.ncbi.nlm.nih.gov/pubmed/35806358
http://dx.doi.org/10.3390/ijms23137353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266842/
https://www.ncbi.nlm.nih.gov/pubmed/35806358
http://dx.doi.org/10.3390/ijms23137353

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