eIF4A1 Inhibitor Suppresses Hyperactive mTOR-Associated Tumors by Inducing Necroptosis and G2/M Arrest

Aberrantly activated mechanistic target of rapamycin (mTOR) signaling pathway stimulates translation initiation/protein synthesis and eventually causes tumors. Targeting these processes thus holds potential for treating mTOR-associated diseases. We tested the potential of eFT226, a sequence-selectiv...

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Detalles Bibliográficos
Autores principales: Han, Luyang, Wu, Yuting, Liu, Fangming, Zhang, Hongbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266907/
https://www.ncbi.nlm.nih.gov/pubmed/35805935
http://dx.doi.org/10.3390/ijms23136932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266907/
https://www.ncbi.nlm.nih.gov/pubmed/35805935
http://dx.doi.org/10.3390/ijms23136932

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