Inhibition of Vascular Endothelial Cadherin Cleavage Prevents Elastic Fiber Alterations and Atherosclerosis Induced by Intermittent Hypoxia in the Mouse Aorta

Intermittent hypoxia (IH), the major feature of obstructive sleep apnea syndrome (OSAS), induces atherosclerosis and elastic fiber alterations. VE-cadherin cleavage is increased in OSAS patients and in an IH-cellular model. It is mediated by HIF-1 and Src-tyr-kinases pathways and results in endothel...

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Detalles Bibliográficos
Autores principales: Harki, Olfa, Bouyon, Sophie, Sallé, Marine, Arco-Hierves, Alejandro, Lemarié, Emeline, Demory, Alexandra, Chirica, Carole, Vilgrain, Isabelle, Pépin, Jean-Louis, Faury, Gilles, Briançon-Marjollet, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266969/
https://www.ncbi.nlm.nih.gov/pubmed/35806017
http://dx.doi.org/10.3390/ijms23137012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266969/
https://www.ncbi.nlm.nih.gov/pubmed/35806017
http://dx.doi.org/10.3390/ijms23137012

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