Aberrant PLN-R14del Protein Interactions Intensify SERCA2a Inhibition, Driving Impaired Ca(2+) Handling and Arrhythmogenesis

Phospholamban (PLN), a key modulator of Ca(2+)-homeostasis, inhibits sarcoplasmic reticulum (SR) calcium-ATPase (SERCA2a) and regulates cardiac contractility. The human PLN mutation R14del has been identified in arrhythmogenic cardiomyopathy patients worldwide and is currently extensively investigat...

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Detalles Bibliográficos
Autores principales: Vafiadaki, Elizabeth, Haghighi, Kobra, Arvanitis, Demetrios A., Kranias, Evangelia G., Sanoudou, Despina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266971/
https://www.ncbi.nlm.nih.gov/pubmed/35805951
http://dx.doi.org/10.3390/ijms23136947

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266971/
https://www.ncbi.nlm.nih.gov/pubmed/35805951
http://dx.doi.org/10.3390/ijms23136947

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