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Aberrant PLN-R14del Protein Interactions Intensify SERCA2a Inhibition, Driving Impaired Ca(2+) Handling and Arrhythmogenesis

Phospholamban (PLN), a key modulator of Ca(2+)-homeostasis, inhibits sarcoplasmic reticulum (SR) calcium-ATPase (SERCA2a) and regulates cardiac contractility. The human PLN mutation R14del has been identified in arrhythmogenic cardiomyopathy patients worldwide and is currently extensively investigat...

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Detalles Bibliográficos
Autores principales:	Vafiadaki, Elizabeth, Haghighi, Kobra, Arvanitis, Demetrios A., Kranias, Evangelia G., Sanoudou, Despina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266971/ https://www.ncbi.nlm.nih.gov/pubmed/35805951 http://dx.doi.org/10.3390/ijms23136947

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