Low-Dose Rifabutin Increases Cytotoxicity in Antimitotic-Drug-Treated Resistant Cancer Cells by Exhibiting Strong P-gp-Inhibitory Activity

The cytotoxicity of various antibiotics at low doses in drug-resistant cancer cells was evaluated. Low doses of rifabutin were found to markedly increase the cytotoxicity of various antimitotic drugs, such as vincristine (VIC), to P-glycoprotein (P-gp)-overexpressing antimitotic-drug-resistant KBV20...

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Detalles Bibliográficos
Autores principales: Lee, Ji Sun, Oh, Yunmoon, Kim, Hyung Sik, Yoon, Sungpil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267098/
https://www.ncbi.nlm.nih.gov/pubmed/35806386
http://dx.doi.org/10.3390/ijms23137383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267098/
https://www.ncbi.nlm.nih.gov/pubmed/35806386
http://dx.doi.org/10.3390/ijms23137383

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