VARS2 Depletion Leads to Activation of the Integrated Stress Response and Disruptions in Mitochondrial Fatty Acid Oxidation

Mutations in mitochondrial aminoacyl-tRNA synthetases (mtARSs) have been reported in patients with mitochondriopathies: most commonly encephalopathy, but also cardiomyopathy. Through a GWAS, we showed possible associations between mitochondrial valyl-tRNA synthetase (VARS2) dysregulations and non-is...

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Detalles Bibliográficos
Autores principales: Kayvanpour, Elham, Wisdom, Michael, Lackner, Maximilian K., Sedaghat-Hamedani, Farbod, Boeckel, Jes-Niels, Müller, Marion, Eghbalian, Rose, Dudek, Jan, Doroudgar, Shirin, Maack, Christoph, Frey, Norbert, Meder, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267100/
https://www.ncbi.nlm.nih.gov/pubmed/35806332
http://dx.doi.org/10.3390/ijms23137327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267100/
https://www.ncbi.nlm.nih.gov/pubmed/35806332
http://dx.doi.org/10.3390/ijms23137327

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