Cargando…

Complete Reaction Phenotyping of Propranolol and 4-Hydroxypropranolol with the 19 Enzymes of the Human UGT1 and UGT2 Families

Propranolol is a competitive non-selective beta-receptor antagonist that is available on the market as a racemic mixture. In the present study, glucuronidation of propranolol and its equipotent phase I metabolite 4-hydroxypropranolol by all 19 members of the human UGT1 and UGT2 families was monitore...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Fan, Liu, Sijie, Wolber, Gerhard, Bureik, Matthias, Parr, Maria Kristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267274/ https://www.ncbi.nlm.nih.gov/pubmed/35806479 http://dx.doi.org/10.3390/ijms23137476

Ejemplares similares

Mutual Modulation of the Activities of Human CYP2D6 and Four UGTs during the Metabolism of Propranolol
por: Yang, Fan, et al.
Publicado: (2023)

Impacts of the Glucuronidase Genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on Tamoxifen Metabolism in Breast Cancer Patients
por: Romero-Lorca, Alicia, et al.
Publicado: (2015)

Correction: Impacts of the Glucuronidase Genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on Tamoxifen Metabolism in Breast Cancer Patients
Publicado: (2015)

Comprehensive Variant Screening of the UGT Gene Family
por: Kim, Jason Yongha, et al.
Publicado: (2014)

Changes in Alprazolam Metabolism by CYP3A43 Mutants
por: Zhao, Jie, et al.
Publicado: (2022)

Differences in UGT1A1, UGT1A7, and UGT1A9 Polymorphisms between Uzbek and Japanese Populations
por: Maeda, Hiromichi, et al.
Publicado: (2014)

Historia de la UGT.
Publicado: (2008)

Predicting Flavonoid UGT Regioselectivity
por: Jackson, Rhydon, et al.
Publicado: (2011)

Functional Expression of All Human Sulfotransferases in Fission Yeast, Assay Development, and Structural Models for Isoforms SULT4A1 and SULT6B1
por: Sun, Yanan, et al.
Publicado: (2020)

Profiling of UGT1A1(*)6, UGT1A1(*)60, UGT1A1(*)93, and UGT1A1(*)28 Polymorphisms in Indonesian Neonates With Hyperbilirubinemia Using Multiplex PCR Sequencing
por: Amandito, Radhian, et al.
Publicado: (2019)

Genome-wide analysis of family-1 UDP glycosyltransferases (UGT) and identification of UGT genes for FHB resistance in wheat (Triticum aestivum L.)
por: He, Yi, et al.
Publicado: (2018)

Commentary: Profiling of UGT1A1(*)6, UGT1A1(*)60, UGT1A1(*)93, and UGT1A1(*)28 Polymorphisms in Indonesian Neonates With Hyperbilirubinemia Using Multiplex PCR Sequencing
por: Heydari, Mohammad Reza, et al.
Publicado: (2020)

Glucuronidation of [6]-shogaol, [8]-shogaol and [10]-shogaol by human tissues and expressed UGT enzymes: identification of UGT2B7 as the major contributor
por: He, Liangliang, et al.
Publicado: (2018)

Association of UGT2B7 and UGT1A4 Polymorphisms with Serum Concentration of Antiepileptic Drugs in Children
por: Du, Zhongliang, et al.
Publicado: (2016)

Polymorphisms of UGT1A1(*)6, UGT1A1(*)27 & UGT1A1(*)28 in three major ethnic groups from Malaysia
por: Teh, L. K., et al.
Publicado: (2012)

Epigenetics and microRNAs in UGT1As
por: Meng, Cui-Lan, et al.
Publicado: (2021)

Genome-Wide Analysis of UGT Genes in Petunia and Identification of PhUGT51 Involved in the Regulation of Salt Resistance
por: Dong, Lili, et al.
Publicado: (2022)

Genotyping of UGT1A1*80 as an Alternative to UGT1A1*28 Genotyping in Spain
por: Bravo-Gómez, Adrián, et al.
Publicado: (2022)

UGT1A1 and UGT1A9 Are Responsible for Phase II Metabolism of Tectorigenin and Irigenin In Vitro
por: Li, Ji, et al.
Publicado: (2022)

The Activity of Members of the UDP-Glucuronosyltransferase Subfamilies UGT1A and UGT2B is Impaired in Patients with Liver Cirrhosis
por: Duthaler, Urs, et al.
Publicado: (2023)

Pharmacogenetics of ugt genes in North African populations
por: Gaibar, M., et al.
Publicado: (2018)

Computational analysis of variation in C. elegans ugts
por: Asif, Muhammad Zaka, et al.
Publicado: (2023)

Differences in salicylic acid glucose conjugations by UGT74F1 and UGT74F2 from Arabidopsis thaliana
por: George Thompson, Alayna M., et al.
Publicado: (2017)

A convenient test system for the identification of CYP4V2 inhibitors
por: Sharma, Shishir, et al.
Publicado: (2021)

Functional diversification of two UGT80 enzymes required for steryl glucoside synthesis in Arabidopsis
por: Stucky, Daniel F., et al.
Publicado: (2015)

Genome-Wide Analysis of the UGT Gene Family and Identification of Flavonoids in Broussonetia papyrifera
por: Wang, Fenfen, et al.
Publicado: (2021)

UGT72, a Major Glycosyltransferase Family for Flavonoid and Monolignol Homeostasis in Plants
por: Speeckaert, Nathanaël, et al.
Publicado: (2022)

Quantitative Systems Pharmacology Model of hUGT1A1‐modRNA Encoding for the UGT1A1 Enzyme to Treat Crigler‐Najjar Syndrome Type 1
por: Apgar, Joshua F., et al.
Publicado: (2018)

Truncated UDP-glucuronosyltransferase (UGT) from a Crigler–Najjar syndrome type II patient colocalizes with intact UGT in the endoplasmic reticulum
por: Suzuki, Masahiro, et al.
Publicado: (2014)

Potential Regulation of UGT2B10 and UGT2B7 by miR-485-5p in Human Liver
por: Sutliff, Aimee K., et al.
Publicado: (2019)

Physiologically‐Based Pharmacokinetic Modeling of the Drug–Drug Interaction of the UGT Substrate Ertugliflozin Following Co‐Administration with the UGT Inhibitor Mefenamic Acid
por: Callegari, Ernesto, et al.
Publicado: (2020)

Association of gallstone and polymorphisms of UGT1A1*27 and UGT1A1*28 in patients with hepatitis B virus-related liver failure
por: Zhuo, Haiyan, et al.
Publicado: (2022)

CORRIGENDUM: Quantitative Systems Pharmacology Model of hUGT1A1‐modRNA Encoding for the UGT1A1 Enzyme to Treat Crigler‐Najjar Syndrome Type 1
por: Apgar, J.F., et al.
Publicado: (2020)

Comparative analysis of involvement of UGT1 and UGT2 splice variants of UDP-galactose transporter in glycosylation of macromolecules in MDCK and CHO cell lines
por: Maszczak-Seneczko, Dorota, et al.
Publicado: (2011)

The evolution of UDP-glycosyl/glucuronosyltransferase 1E (UGT1E) genes in bird lineages is linked to feeding habits but UGT2 genes is not
por: Kawai, Yusuke K., et al.
Publicado: (2018)

Effects of ABCB1, UGT1A1, and UGT1A9 Genetic Polymorphisms on the Pharmacokinetics of Sitafloxacin Granules in Healthy Subjects
por: Sun, Lu‐Ning, et al.
Publicado: (2020)

Identifying and applying a highly selective probe to simultaneously determine the O-glucuronidation activity of human UGT1A3 and UGT1A4
por: Jiang, Li, et al.
Publicado: (2015)

Two UGT84 Family Glycosyltransferases Catalyze a Critical Reaction of Hydrolyzable Tannin Biosynthesis in Pomegranate (Punica granatum)
por: Ono, Nadia N., et al.
Publicado: (2016)

Corticosteroid Biosynthesis Revisited: No Direct Hydroxylation of Pregnenolone by Steroid 21-Hydroxylase
por: Loke, Steffen, et al.
Publicado: (2021)

The reference liver—CYP450 and UGT enzymes in healthy donor and metastatic livers: the impact of genotype
por: Kurzawski, Mateusz, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_cktejfmif64k1a9hgf76vak35r