Continued Structural Exploration of Sulfocoumarin as Selective Inhibitor of Tumor-Associated Human Carbonic Anhydrases IX and XII

A series of new 3- and 7-substituted sulfocoumarins was obtained by several cyclization reactions and subsequent derivatization for screening as prodrug inhibitors of the human (h) cancer-associated carbonic anhydrases (CAs) IX and XII. All products were ineffective inhibitors against the off-target...

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Detalles Bibliográficos
Autores principales: Giovannuzzi, Simone, Capasso, Clemente, Nocentini, Alessio, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267968/
https://www.ncbi.nlm.nih.gov/pubmed/35807318
http://dx.doi.org/10.3390/molecules27134076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267968/
https://www.ncbi.nlm.nih.gov/pubmed/35807318
http://dx.doi.org/10.3390/molecules27134076

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