Insights into the Allosteric Effect of SENP1 Q597A Mutation on the Hydrolytic Reaction of SUMO1 via an Integrated Computational Study

Small ubiquitin-related modifier (SUMO)-specific protease 1 (SENP1) is a cysteine protease that catalyzes the cleavage of the C-terminus of SUMO1 for the processing of SUMO precursors and deSUMOylation of target proteins. SENP1 is considered to be a promising target for the treatment of hepatocellul...

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Detalles Bibliográficos
Autores principales: Ji, Mingfei, Chai, Zongtao, Chen, Jie, Li, Gang, Li, Qiang, Li, Miao, Ding, Yelei, Lu, Shaoyong, Ju, Guanqun, Hou, Jianquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268427/
https://www.ncbi.nlm.nih.gov/pubmed/35807394
http://dx.doi.org/10.3390/molecules27134149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268427/
https://www.ncbi.nlm.nih.gov/pubmed/35807394
http://dx.doi.org/10.3390/molecules27134149

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