From Repurposing to Redesign: Optimization of Boceprevir to Highly Potent Inhibitors of the SARS-CoV-2 Main Protease †

The main protease (M(pro)) of the betacoronavirus SARS-CoV-2 is an attractive target for the development of treatments for COVID-19. Structure-based design is a successful approach to discovering new inhibitors of the M(pro). Starting from crystal structures of the M(pro) in complexes with the Hepat...

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Detalles Bibliográficos
Autores principales: Göhl, Matthias, Zhang, Linlin, El Kilani, Haifa, Sun, Xinyuanyuan, Zhang, Kaixuan, Brönstrup, Mark, Hilgenfeld, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268446/
https://www.ncbi.nlm.nih.gov/pubmed/35807537
http://dx.doi.org/10.3390/molecules27134292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268446/
https://www.ncbi.nlm.nih.gov/pubmed/35807537
http://dx.doi.org/10.3390/molecules27134292

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