Sustainable Protocol for the Synthesis of 2′,3′-Dideoxynucleoside and 2′,3′-Didehydro-2′,3′-dideoxynucleoside Derivatives

An improved protocol for the transformation of ribonucleosides into 2′,3′-dideoxynucleoside and 2′,3′-didehydro-2′,3′-dideoxynucleoside derivatives, including the anti-HIV drugs stavudine (d4T), zalcitabine (ddC) and didanosine (ddI), was established. The process involves radical deoxygenation of xa...

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Detalles Bibliográficos
Autores principales: Martín-Nieves, Virginia, Sanghvi, Yogesh S., Fernández, Susana, Ferrero, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268517/
https://www.ncbi.nlm.nih.gov/pubmed/35807233
http://dx.doi.org/10.3390/molecules27133993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268517/
https://www.ncbi.nlm.nih.gov/pubmed/35807233
http://dx.doi.org/10.3390/molecules27133993

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