Synthesis of Pyrimidine Conjugates with 4-(6-Amino-hexanoyl)-7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine and Evaluation of Their Antiviral Activity

A series of pyrimidine conjugates containing a fragment of racemic 7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine and its (S)-enantiomer attached via a 6-aminohexanoyl fragment were synthesized by the reaction of nucleophilic substitution of chlorine in various chloropyrimidines. The structur...

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Detalles Bibliográficos
Autores principales: Krasnov, Victor P., Musiyak, Vera V., Levit, Galina L., Gruzdev, Dmitry A., Andronova, Valeriya L., Galegov, Georgii A., Orshanskaya, Iana R., Sinegubova, Ekaterina O., Zarubaev, Vladimir V., Charushin, Valery N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268552/
https://www.ncbi.nlm.nih.gov/pubmed/35807481
http://dx.doi.org/10.3390/molecules27134236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268552/
https://www.ncbi.nlm.nih.gov/pubmed/35807481
http://dx.doi.org/10.3390/molecules27134236

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