Design, Synthesis, In Silico and In Vitro Studies of New Immunomodulatory Anticancer Nicotinamide Derivatives Targeting VEGFR-2

VEGFR-2, the subtype receptor tyrosine kinase (RTK) responsible for angiogenesis, is expressed in various cancer cells. Thus, VEGFER-2 inhibition is an efficient approach for the discovery of new anticancer agents. Accordingly, a new set of nicotinamide derivatives were designed and synthesized to b...

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Detalles Bibliográficos
Autores principales: Yousef, Reda G., Eldehna, Wagdy M., Elwan, Alaa, Abdelaziz, Abdelaziz S., Mehany, Ahmed B. M., Gobaara, Ibraheem M. M., Alsfouk, Bshra A., Elkaeed, Eslam B., Metwaly, Ahmed M., Eissa, Ibrahim H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268560/
https://www.ncbi.nlm.nih.gov/pubmed/35807326
http://dx.doi.org/10.3390/molecules27134079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268560/
https://www.ncbi.nlm.nih.gov/pubmed/35807326
http://dx.doi.org/10.3390/molecules27134079

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