A Class I HDAC Inhibitor Rescues Synaptic Damage and Neuron Loss in APP-Transfected Cells and APP/PS1 Mice through the GRIP1/AMPA Pathway

As a neurodegenerative disease, Alzheimer’s disease (AD) seriously affects the health of older people. Changes in synapses occur first over the course of the disease, perhaps even before the formation of Aβ plaques. Histone deacetylase (HDAC) mediates the damage of Aβ oligomers to dendritic spines....

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Detalles Bibliográficos
Autores principales: Han, Ying, Chen, Le, Liu, Jingyun, Chen, Jie, Wang, Chunyang, Guo, Yu, Yu, Xuebin, Zhang, Chenghong, Chu, Haiying, Ma, Haiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268711/
https://www.ncbi.nlm.nih.gov/pubmed/35807406
http://dx.doi.org/10.3390/molecules27134160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268711/
https://www.ncbi.nlm.nih.gov/pubmed/35807406
http://dx.doi.org/10.3390/molecules27134160

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