Cargando…

Remyelination in humans due to a retinoid‐X receptor agonist is age‐dependent

Remyelination efficiency declines with advancing age in animal models, but this has been harder to demonstrate in people with multiple sclerosis. We show that bexarotene, a putatively remyelinating retinoid‐X receptor agonist, shortened the visual evoked potential latency in patients with chronic op...

Descripción completa

Detalles Bibliográficos
Autores principales:	McMurran, Christopher E., Mukherjee, Trisha, Brown, J William L., Michell, Andrew W., Chard, Declan T., Franklin, Robin J. M., Coles, Alasdair J., Cunniffe, Nick G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Brief Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268872/ https://www.ncbi.nlm.nih.gov/pubmed/35587315 http://dx.doi.org/10.1002/acn3.51595

Ejemplares similares

Promoting remyelination in multiple sclerosis
por: Cunniffe, Nick, et al.
Publicado: (2019)

CNS Remyelination and the Innate Immune System
por: McMurran, Christopher E., et al.
Publicado: (2016)

Correcting gut dysbiosis can ameliorate inflammation and promote remyelination in multiple sclerosis – No
por: McMurran, Christopher E
Publicado: (2021)

Remyelination varies between and within lesions in multiple sclerosis following bexarotene
por: Brown, J. William L., et al.
Publicado: (2022)

The MS Remyelinating Drug Bexarotene (an RXR Agonist) Promotes Induction of Human Tregs and Suppresses Th17 Differentiation In Vitro
por: Gaunt, Christopher M., et al.
Publicado: (2021)

Retinoid Agonists in the Targeting of Heterotopic Ossification
por: Pignolo, Robert J., et al.
Publicado: (2021)

The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination
por: McMurran, Christopher E., et al.
Publicado: (2019)

Remyelination and ageing: Reversing the ravages of time
por: Neumann, Bjoern, et al.
Publicado: (2019)

Of Retinoids and Organotins: The Evolution of the Retinoid X Receptor in Metazoa
por: Fonseca, Elza, et al.
Publicado: (2020)

A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation
por: Morichika, Daisuke, et al.
Publicado: (2019)

Efficient Remyelination Requires DNA Methylation
por: Moyon, Sarah, et al.
Publicado: (2017)

Potential Retinoid X Receptor Agonists for Treating Alzheimer's Disease from Traditional Chinese Medicine
por: Chen, Kuan-Chung, et al.
Publicado: (2014)

Retinoid X Receptor Antagonists
por: Watanabe, Masaki, et al.
Publicado: (2018)

Additional Interventions to Enhance the Effectiveness of Individual Placement and Support: A Rapid Evidence Assessment
por: Boycott, Naomi, et al.
Publicado: (2012)

The process of stopping recruitment and trial treatment in a trial of a psychological therapy for people with personality disorder following a safety alert
por: Day, Florence, et al.
Publicado: (2013)

‘Things often get worse before they get better’: participants’ responses to the cessation of recruitment and trial treatment in a trial of a psychological therapy for people with personality disorder following a safety alert. (A missed opportunity for collaboration?)
por: Day, Florence, et al.
Publicado: (2013)

Cost implications of treatment non-completion in a forensic personality disorder service
por: Sampson, Christopher James, et al.
Publicado: (2013)

Retinoid X receptor agonist LG100268 modulates the immune microenvironment in preclinical breast cancer models
por: Leal, Ana S., et al.
Publicado: (2019)

A Retinoid X Receptor Agonist Directed to the Large Intestine Ameliorates T-Cell-Mediated Colitis in Mice
por: Matsumoto, Ryohtaroh, et al.
Publicado: (2021)

Retinoid-X receptor agonists increase thyroid hormone competence in lower jaw remodeling of pre-metamorphic Xenopus laevis tadpoles
por: Mengeling, Brenda J., et al.
Publicado: (2022)

What roles do growth factors play in CNS remyelination?
por: Franklin, Robin J.M., et al.
Publicado: (2001)

Retinoic Acid and Retinoid X Receptors
por: Schubert, Michael, et al.
Publicado: (2023)

Inhibition of Carrageenan-Induced Cutaneous Inflammation by PPAR Agonists Is Dependent on Hepatocyte-Specific Retinoid X ReceptorAlpha
por: Wan, Yu-Jui Yvonne, et al.
Publicado: (2006)

Retinoid X Receptor Agonists Upregulate Genes Responsible for the Biosynthesis of All-Trans-Retinoic Acid in Human Epidermis
por: Wu, Lizhi, et al.
Publicado: (2016)

Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma
por: Fujii, Utako, et al.
Publicado: (2017)

The Impact of Working with Farm Animals on People with Offending Histories: A Scoping Review
por: Payne, Libby, et al.
Publicado: (2022)

The Crucial Involvement of Retinoid X Receptors in DDE Neurotoxicity
por: Wnuk, A., et al.
Publicado: (2015)

A selective retinoid X receptor agonist bexarotene (LGD1069, targretin) inhibits angiogenesis and metastasis in solid tumours
por: Yen, W-C, et al.
Publicado: (2006)

Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression
por: Burrage, Peter S, et al.
Publicado: (2008)

GABA(B) receptor agonist baclofen promotes central nervous system remyelination
por: Serrano‐Regal, Mari Paz, et al.
Publicado: (2022)

Schwann cell remyelination of the central nervous system: why does it happen and what are the benefits?
por: Chen, Civia Z., et al.
Publicado: (2021)

The addition of a goal-based motivational interview to treatment as usual to enhance engagement and reduce dropouts in a personality disorder treatment service: results of a feasibility study for a randomized controlled trial
por: McMurran, Mary, et al.
Publicado: (2013)

A patient with sporadic Creutzfeldt–Jakob disease: challenges of rare diseases in the COVID-19 era
por: McMurran, Christopher E, et al.
Publicado: (2020)

Vitamin D receptor–retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation
por: de la Fuente, Alerie Guzman, et al.
Publicado: (2015)

Retinoids in Oncology
por: Rustin, G.J.S.
Publicado: (1994)

TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination
por: Gouna, Garyfallia, et al.
Publicado: (2021)

Involvement of the Retinoid X Receptor Ligand in the Anti-Inflammatory Effect Induced by Peroxisome Proliferator-Activated Receptor γ Agonist In Vivo
por: Yamamoto, Atsuki, et al.
Publicado: (2011)

The recording of adverse events from psychological treatments in clinical trials: evidence from a review of NIHR-funded trials
por: Duggan, Conor, et al.
Publicado: (2014)

Acyclic retinoid in chemoprevention of hepatocellular carcinoma: Targeting phosphorylated retinoid X receptor-α for prevention of liver carcinogenesis
por: Shimizu, Masahito, et al.
Publicado: (2012)

Role of PPARs and Retinoid X Receptors in the Regulation of Lung Maturation and Development
por: Simon, Dawn M., et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_vp6kbt8s13ue1uva5n5gj12i69