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Probing conformational changes during activation of ASIC1a by an optical tweezer and by methanethiosulfonate-based cross-linkers
Acid-sensing ion channels (ASICs) are neuronal, proton-gated, Na(+)-selective ion channels. They are involved in various physiological and pathological processes such as neurodegeneration after stroke, pain sensation, fear behavior and learning. To obtain information on the activation mechanism of A...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269482/ https://www.ncbi.nlm.nih.gov/pubmed/35802631 http://dx.doi.org/10.1371/journal.pone.0270762 |