Progerin modulates the IGF-1R/Akt signaling involved in aging

Progerin, a product of LMNA mutation, leads to multiple nuclear abnormalities in patients with Hutchinson-Gilford progeria syndrome (HGPS), a devastating premature aging disorder. Progerin also accumulates during physiological aging. Here, we demonstrate that impaired insulin-like growth factor 1 re...

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Detalles Bibliográficos
Autores principales: Jiang, Bo, Wu, Xuan, Meng, Fang, Si, Limiao, Cao, Sunrun, Dong, Yuqing, Sun, Huayi, Lv, Mengzhu, Xu, Hongde, Bai, Ning, Guo, Qiqiang, Song, Xiaoyu, Yu, Yang, Guo, Wendong, Yi, Fei, Zhou, Tingting, Li, Xiaoman, Feng, Yanling, Wang, Zhuo, Zhang, Dan, Guan, Yi, Ma, Mengtao, Liu, Jingwei, Li, Xining, Zhao, Weidong, Liu, Baohua, Finkel, Toren, Cao, Liu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269893/
https://www.ncbi.nlm.nih.gov/pubmed/35857466
http://dx.doi.org/10.1126/sciadv.abo0322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269893/
https://www.ncbi.nlm.nih.gov/pubmed/35857466
http://dx.doi.org/10.1126/sciadv.abo0322

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