Histone deacetylase inhibitor, panobinostat, exerts anti-proliferative effect with partial normalization from aberrant epigenetic states on granulosa cell tumor cell lines

The prognosis of the patients with inoperable or advanced granulosa cell tumors (GCTs) is still poor, and therefore it is important to establish a novel treatment strategy. Here we investigated the in vitro effects of a histone deacetylase inhibitor, panobinostat (PS) on two GCT cell lines (KGN and...

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Detalles Bibliográficos
Autores principales: Hazama, Yukiko, Tsujioka, Takayuki, Kitanaka, Akira, Tohyama, Kaoru, Shimoya, Koichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269920/
https://www.ncbi.nlm.nih.gov/pubmed/35802681
http://dx.doi.org/10.1371/journal.pone.0271245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269920/
https://www.ncbi.nlm.nih.gov/pubmed/35802681
http://dx.doi.org/10.1371/journal.pone.0271245

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