Cargando…
Modeling recapitulates the heterogeneous outcomes of SARS-CoV-2 infection and quantifies the differences in the innate immune and CD8 T-cell responses between patients experiencing mild and severe symptoms
SARS-CoV-2 infection results in highly heterogeneous outcomes, from cure without symptoms to acute respiratory distress and death. Empirical evidence points to the prominent roles of innate immune and CD8 T-cell responses in determining the outcomes. However, how these immune arms act in concert to...
Autores principales: | Chatterjee, Budhaditya, Singh Sandhu, Harshbir, Dixit, Narendra M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269964/ https://www.ncbi.nlm.nih.gov/pubmed/35759522 http://dx.doi.org/10.1371/journal.ppat.1010630 |
Ejemplares similares
-
Cellular Metabolic Heterogeneity In Vivo Is Recapitulated in Tumor Organoids()
por: Sharick, Joe T., et al.
Publicado: (2019) -
An organoids biobank for recapitulating tumor heterogeneity and personalized medicine
por: Yang, Hui, et al.
Publicado: (2020) -
Innate-like NKp30(+)CD8(+) T cells armed with TCR/CAR target tumor heterogeneity
por: Correia, Margareta P., et al.
Publicado: (2021) -
Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells
por: Mudd, Joseph C., et al.
Publicado: (2018) -
Towards multiscale modeling of the CD8(+) T cell response to viral infections
por: Baral, Subhasish, et al.
Publicado: (2019)