ANGPTL4 silencing via antisense oligonucleotides reduces plasma triglycerides and glucose in mice without causing lymphadenopathy

Angiopoietin-like 4 (ANGPTL4) is an important regulator of plasma triglyceride (TG) levels and an attractive pharmacological target for lowering plasma lipids and reducing cardiovascular risk. Here, we aimed to study the efficacy and safety of silencing ANGPTL4 in the livers of mice using hepatocyte...

Descripción completa

Detalles Bibliográficos
Autores principales: Deng, Mingjuan, Kutrolli, Elda, Sadewasser, Anne, Michel, Sven, Joibari, Masoumeh Motamedi, Jaschinski, Frank, Olivecrona, Gunilla, Nilsson, Stefan K., Kersten, Sander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270256/
https://www.ncbi.nlm.nih.gov/pubmed/35667416
http://dx.doi.org/10.1016/j.jlr.2022.100237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270256/
https://www.ncbi.nlm.nih.gov/pubmed/35667416
http://dx.doi.org/10.1016/j.jlr.2022.100237

Ejemplares similares