A novel antiproliferative PKCα-Ras-ERK signaling axis in intestinal epithelial cells

We have previously shown that the serine/threonine kinase PKCα triggers MAPK/ERK kinase (MEK)-dependent G(1)→S cell cycle arrest in intestinal epithelial cells, characterized by downregulation of cyclin D1 and inhibitor of DNA-binding protein 1 (Id1) and upregulation of the cyclin-dependent kinase i...

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Detalles Bibliográficos
Autores principales: Kaur, Navneet, Lum, Michelle A., Lewis, Robert E., Black, Adrian R., Black, Jennifer D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270260/
https://www.ncbi.nlm.nih.gov/pubmed/35697074
http://dx.doi.org/10.1016/j.jbc.2022.102121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270260/
https://www.ncbi.nlm.nih.gov/pubmed/35697074
http://dx.doi.org/10.1016/j.jbc.2022.102121

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