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A novel antiproliferative PKCα-Ras-ERK signaling axis in intestinal epithelial cells
We have previously shown that the serine/threonine kinase PKCα triggers MAPK/ERK kinase (MEK)-dependent G(1)→S cell cycle arrest in intestinal epithelial cells, characterized by downregulation of cyclin D1 and inhibitor of DNA-binding protein 1 (Id1) and upregulation of the cyclin-dependent kinase i...
Autores principales: | Kaur, Navneet, Lum, Michelle A., Lewis, Robert E., Black, Adrian R., Black, Jennifer D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270260/ https://www.ncbi.nlm.nih.gov/pubmed/35697074 http://dx.doi.org/10.1016/j.jbc.2022.102121 |
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