Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines

PURPOSE: Noonan syndrome with multiple lentigines (NSML) is an autosomal dominant disorder presenting with hypertrophic cardiomyopathy (HCM). Up to 85% of NSML cases are caused by mutations in the PTPN11 gene that encodes for the Src homology 2 (SH2) domain-containing protein tyrosine phosphatase 2...

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Detalles Bibliográficos
Autores principales: Yi, Jae-Sung, Perla, Sravan, Huang, Yan, Mizuno, Kana, Giordano, Frank J., Vinks, Alexander A., Bennett, Anton M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270274/
https://www.ncbi.nlm.nih.gov/pubmed/33689087
http://dx.doi.org/10.1007/s10557-021-07169-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270274/
https://www.ncbi.nlm.nih.gov/pubmed/33689087
http://dx.doi.org/10.1007/s10557-021-07169-z

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