Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture

The transmembrane serine protease 2 (TMPRSS2) primes the SARS-CoV-2 Spike (S) protein for host cell entry and represents a promising target for COVID-19 therapy. Here we describe the in silico development and in vitro characterization of peptidomimetic TMPRSS2 inhibitors. Molecular docking studies i...

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Detalles Bibliográficos
Autores principales: Wettstein, Lukas, Knaff, Philip Maximilian, Kersten, Christian, Müller, Patrick, Weil, Tatjana, Conzelmann, Carina, Müller, Janis A, Brückner, Maximilian, Hoffmann, Markus, Pöhlmann, Stefan, Schirmeister, Tanja, Landfester, Katharina, Münch, Jan, Mailänder, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270327/
https://www.ncbi.nlm.nih.gov/pubmed/35804152
http://dx.doi.org/10.1038/s42003-022-03613-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270327/
https://www.ncbi.nlm.nih.gov/pubmed/35804152
http://dx.doi.org/10.1038/s42003-022-03613-4

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