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Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture

The transmembrane serine protease 2 (TMPRSS2) primes the SARS-CoV-2 Spike (S) protein for host cell entry and represents a promising target for COVID-19 therapy. Here we describe the in silico development and in vitro characterization of peptidomimetic TMPRSS2 inhibitors. Molecular docking studies i...

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Detalles Bibliográficos
Autores principales:	Wettstein, Lukas, Knaff, Philip Maximilian, Kersten, Christian, Müller, Patrick, Weil, Tatjana, Conzelmann, Carina, Müller, Janis A, Brückner, Maximilian, Hoffmann, Markus, Pöhlmann, Stefan, Schirmeister, Tanja, Landfester, Katharina, Münch, Jan, Mailänder, Volker
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270327/ https://www.ncbi.nlm.nih.gov/pubmed/35804152 http://dx.doi.org/10.1038/s42003-022-03613-4

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