Cargando…

Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, and therapeutic options for advanced HCC are limited. Here, we observe that intestinal dysbiosis affects antitumor immune surveillance and drives liver disease progression towards cancer. Dysbiotic microbiota, as s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schneider, Kai Markus, Mohs, Antje, Gui, Wenfang, Galvez, Eric J. C., Candels, Lena Susanna, Hoenicke, Lisa, Muthukumarasamy, Uthayakumar, Holland, Christian H., Elfers, Carsten, Kilic, Konrad, Schneider, Carolin Victoria, Schierwagen, Robert, Strnad, Pavel, Wirtz, Theresa H., Marschall, Hanns-Ulrich, Latz, Eicke, Lelouvier, Benjamin, Saez-Rodriguez, Julio, de Vos, Willem, Strowig, Till, Trebicka, Jonel, Trautwein, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270328/ https://www.ncbi.nlm.nih.gov/pubmed/35803930 http://dx.doi.org/10.1038/s41467-022-31312-5

Ejemplares similares

Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury
por: Schneider, Kai Markus, et al.
Publicado: (2020)

Intestinal Microbiota Protects against MCD Diet-Induced Steatohepatitis
por: Schneider, Kai Markus, et al.
Publicado: (2019)

Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis
por: Gui, Wenfang, et al.
Publicado: (2023)

Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis
por: Alvarez-Silva, Camila, et al.
Publicado: (2019)

Trust is good, control is better: technical considerations in blood microbiome analysis
por: Schierwagen, Robert, et al.
Publicado: (2020)

Microbiota of vaccinated and non-vaccinated clinically inconspicuous and conspicuous piglets under natural Lawsonia intracellularis infection
por: Hankel, Julia, et al.
Publicado: (2022)

Managing portal hypertension in patients with liver cirrhosis
por: Sauerbruch, Tilman, et al.
Publicado: (2018)

A New Treatment for Chronic Hepatitis B and D Offers Novel Insights Into Obesity and Hepatic Steatosis
por: Schierwagen, Robert, et al.
Publicado: (2020)

Beta-blockers in patients with liver cirrhosis: Pragmatism or perfection?
por: Sauerbruch, Tilman, et al.
Publicado: (2023)

PLA2G7: a new player in shaping energy metabolism and lifespan
por: Candels, Lena Susanna, et al.
Publicado: (2022)

High Dietary Intake of Rye Affects Porcine Gut Microbiota in a Salmonella Typhimurium Infection Study
por: Hankel, Julia, et al.
Publicado: (2022)

Successful Fecal Microbiota Transplantation in a Patient with Severe Complicated Clostridium difficile Infection after Liver Transplantation
por: Schneider, Kai Markus, et al.
Publicado: (2018)

Extracellular Matrix Remodeling in Chronic Liver Disease
por: Ortiz, Cristina, et al.
Publicado: (2021)

Liver Fibrosis in HIV Patients Receiving a Modern cART: Which Factors Play a Role?
por: Mohr, Raphael, et al.
Publicado: (2015)

Hepatic inflammasome activation as origin of Interleukin-1α and Interleukin-1β in liver cirrhosis
por: Praktiknjo, Michael, et al.
Publicado: (2021)

The Role of miRNA-34a as a Prognostic Biomarker for Cirrhotic Patients with Portal Hypertension Receiving TIPS
por: Jansen, Christian, et al.
Publicado: (2014)

NLRP6 Inflammasome Modulates Disease Progression in a Chronic-Plus-Binge Mouse Model of Alcoholic Liver Disease
por: Mainz, Rebecca Elena, et al.
Publicado: (2022)

Microbiome Patterns in Matched Bile, Duodenal, Pancreatic Tumor Tissue, Drainage, and Stool Samples: Association with Preoperative Stenting and Postoperative Pancreatic Fistula Development
por: Langheinrich, Melanie, et al.
Publicado: (2020)

Novel Rat Model of Repetitive Portal Venous Embolization Mimicking Human Non-Cirrhotic Idiopathic Portal Hypertension
por: Klein, Sabine, et al.
Publicado: (2016)

The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis
por: Torres, Sandra, et al.
Publicado: (2021)

MicroRNA-155 is upregulated in ascites in patients with spontaneous bacterial peritonitis
por: Lutz, Philipp, et al.
Publicado: (2017)

Etiology and Complications of Portal Vein Thrombosis
por: Trebicka, Jonel, et al.
Publicado: (2014)

Systemic MCP-1 Levels Derive Mainly From Injured Liver and Are Associated With Complications in Cirrhosis
por: Queck, Alexander, et al.
Publicado: (2020)

Return-to-health effect of modern combined antiretroviral therapy potentially predisposes HIV patients to hepatic steatosis
por: Mohr, Raphael, et al.
Publicado: (2018)

Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis
por: Schierwagen, Robert, et al.
Publicado: (2015)

Variation in Bile Microbiome by the Etiology of Cholestatic Liver Disease
por: Tyc, Olaf, et al.
Publicado: (2020)

Experimental liver fibrosis research: update on animal models, legal issues and translational aspects
por: Liedtke, Christian, et al.
Publicado: (2013)

Hepatobiliary phenotype of individuals with chronic intestinal disorders
por: Voss, Jessica, et al.
Publicado: (2021)

Colon Cancer Microbiome Landscaping: Differences in Right- and Left-Sided Colon Cancer and a Tumor Microbiome-Ileal Microbiome Association
por: Kneis, Barbara, et al.
Publicado: (2023)

Balance between macrophage migration inhibitory factor and sCD74 predicts outcome in patients with acute decompensation of cirrhosis
por: Wirtz, Theresa H., et al.
Publicado: (2020)

Anpassung der Therapie von gastroenterologischen und hepatologischen Erkrankungen bei COVID-19-Infektion
por: Trebicka, Jonel
Publicado: (2021)

Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS
por: Queck, Alexander, et al.
Publicado: (2020)

microRNA‐200a: A stage‐dependent biomarker and predictor of steatosis and liver cell injury in human immunodeficiency virus patients
por: Austermann, Christian, et al.
Publicado: (2017)

HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins
por: Bertheloot, Damien, et al.
Publicado: (2017)

Reduced intestinal lipid absorption improves glucose metabolism in aged G2-Terc knockout mice
por: Liu, Xue, et al.
Publicado: (2023)

Removable denture is a risk indicator for peri-implantitis and facilitates expansion of specific periodontopathogens: a cross-sectional study
por: Grischke, Jasmin, et al.
Publicado: (2021)

Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis
por: Klein, Sabine, et al.
Publicado: (2015)

Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis
por: Benz, Fabian, et al.
Publicado: (2020)

Serum markers of the extracellular matrix remodeling reflect antifibrotic therapy in bile-duct ligated rats
por: Schierwagen, Robert, et al.
Publicado: (2013)

β-Arrestin2 is increased in liver fibrosis in humans and rodents
por: Schierwagen, Robert, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_4lbqh4qf7c9jnu8q0q99qtpt2b