PRMT5 activates AKT via methylation to promote tumor metastasis

Protein arginine methyltransferase 5 (PRMT5) is the primary methyltransferase generating symmetric-dimethyl-arginine marks on histone and non-histone proteins. PRMT5 dysregulation is implicated in multiple oncogenic processes. Here, we report that PRMT5-mediated methylation of protein kinase B (AKT)...

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Detalles Bibliográficos
Autores principales: Huang, Lei, Zhang, Xiao-Ou, Rozen, Esteban J., Sun, Xiaomei, Sallis, Benjamin, Verdejo-Torres, Odette, Wigglesworth, Kim, Moon, Daniel, Huang, Tingting, Cavaretta, John P., Wang, Gang, Zhang, Lei, Shohet, Jason M., Lee, Mary M., Wu, Qiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270419/
https://www.ncbi.nlm.nih.gov/pubmed/35803962
http://dx.doi.org/10.1038/s41467-022-31645-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270419/
https://www.ncbi.nlm.nih.gov/pubmed/35803962
http://dx.doi.org/10.1038/s41467-022-31645-1

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