Cargando…

STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is associated with an incredibly dense stroma, which contributes to its recalcitrance to therapy. Cancer-associated fibroblasts (CAFs) are one of the most abundant cell types within the PDAC stroma and have context-dependent regulation of tumor progression in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lefler, Julia E, MarElia-Bennett, Catherine B, Thies, Katie A, Hildreth, Blake E, Sharma, Sudarshana M, Pitarresi, Jason R, Han, Lu, Everett, Caroline, Koivisto, Christopher, Cuitino, Maria C, Timmers, Cynthia D, O’Quinn, Elizabeth, Parrish, Melodie, Romeo, Martin J, Linke, Amanda J, Hobbs, G Aaron, Leone, Gustavo, Guttridge, Denis C, Zimmers, Teresa A, Lesinski, Gregory B, Ostrowski, Michael C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270499/ https://www.ncbi.nlm.nih.gov/pubmed/35803738 http://dx.doi.org/10.26508/lsa.202201460

Ejemplares similares

Generation of a pancreatic cancer model using a Pdx1-Flp recombinase knock-in allele
por: Wu, Jinghai, et al.
Publicado: (2017)

Anti-IL-6 and PD-L1 antibody combination therapy reduces tumor progression in murine models of pancreatic cancer
por: Mace, Thomas, et al.
Publicado: (2015)

Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia()
por: Pitarresi, Jason R., et al.
Publicado: (2016)

The impact of inflammation and acute phase activation in cancer cachexia
por: Robinson, Tyler P., et al.
Publicado: (2023)

Deep learning tools and modeling to estimate the temporal expression of cell cycle proteins from 2D still images
por: Pécot, Thierry, et al.
Publicado: (2022)

Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth
por: Pitarresi, Jason R, et al.
Publicado: (2018)

The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis
por: Han, Lu, et al.
Publicado: (2023)

Modeling Human Cancer-induced Cachexia
por: Talbert, Erin E., et al.
Publicado: (2019)

BSCI-11. STROMAL PLATELET DERIVED GROWTH FACTOR RECEPTOR-β (PDGFRβ) PROMOTES BREAST CANCER BRAIN METASTASIS
por: Thies, Katie, et al.
Publicado: (2019)

TNF Inhibits Notch-1 in Skeletal Muscle Cells by Ezh2 and DNA Methylation Mediated Repression: Implications in Duchenne Muscular Dystrophy
por: Acharyya, Swarnali, et al.
Publicado: (2010)

Eomes partners with PU.1 and MITF to Regulate Transcription Factors Critical for osteoclast differentiation
por: Carey, Heather A., et al.
Publicado: (2018)

Protein Kinase C Beta in the Tumor Microenvironment Promotes Mammary Tumorigenesis
por: Wallace, Julie A., et al.
Publicado: (2014)

Circulating PANDER concentration is associated with increased HbA1c and fasting blood glucose in Type 2 diabetic subjects
por: MarElia, Catherine B., et al.
Publicado: (2018)

Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar–ductal metaplasia
por: Liu, Xin, et al.
Publicado: (2016)

Stromal PDGFR-α Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth
por: Hammer, Anisha M., et al.
Publicado: (2017)

STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia
por: Bonetto, Andrea, et al.
Publicado: (2011)

Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer
por: Mace, Thomas A., et al.
Publicado: (2015)

Photoshop 6 shop manual
por: O'Quinn, Donnie
Publicado: (2002)

Anemarrhena asphodeloides Bunge and its constituent timosaponin‐AIII induce cell cycle arrest and apoptosis in pancreatic cancer cells
por: MarElia, Catherine B., et al.
Publicado: (2018)

Nikola Tesla for kids: his life, ideas, and inventions, with 21 activities
por: O'Quinn, Amy M
Publicado: (2019)

CSF1-ETS2 Induced microRNA in Myeloid Cells Promote Metastatic Tumor Growth
por: Mathsyaraja, Haritha, et al.
Publicado: (2014)

Circulating monocyte chemoattractant protein‐1 (MCP‐1) is associated with cachexia in treatment‐naïve pancreatic cancer patients
por: Talbert, Erin E., et al.
Publicado: (2018)

Type 2 dendritic cells mediate control of cytotoxic T cell resistant tumors
por: Iwanowycz, Stephen, et al.
Publicado: (2021)

Defining the Structural Stability Field of Disordered Fluorite Oxides
por: O’Quinn, Eric C., et al.
Publicado: (2021)

Recurrent lesion on toe of young man
por: O'Quinn, Marguerite, et al.
Publicado: (2020)

MicroRNA 17-92 Cluster Mediates ETS1 and ETS2-Dependent RAS-Oncogenic Transformation
por: Kabbout, Mohamed, et al.
Publicado: (2014)

Enhanced glucose tolerance in pancreatic-derived factor (PANDER) knockout C57BL/6 mice
por: Moak, Shari L., et al.
Publicado: (2014)

Daily patient-reported health status assessment improvements with benralizumab for patients with severe, uncontrolled eosinophilic asthma
por: O’Quinn, Sean, et al.
Publicado: (2019)

Virtual Sport-Based Positive Youth Development During the COVID-19 Pandemic
por: Bates, Samantha, et al.
Publicado: (2021)

Whole-exome tumor sequencing study in biliary cancer patients with a response to MEK inhibitors
por: Ahn, Daniel H., et al.
Publicado: (2015)

An invitation to the 2nd Cancer Cachexia Conference, Montréal, Canada
por: Guttridge, Denis, et al.
Publicado: (2014)

Pubertal exposure to dietary advanced glycation end products disrupts ductal morphogenesis and induces atypical hyperplasia in the mammary gland
por: Krisanits, Bradley A., et al.
Publicado: (2023)

4124 An innovative Tool for Completing the Clinical and Translational Science Award (CTSA) Research Performance Progress Report (RPPR) using REDCap
por: Subramain, Maran, et al.
Publicado: (2020)

Evaluation of the contribution of tenderness, juiciness, and flavor to the overall consumer beef eating experience
por: O’Quinn, Travis G, et al.
Publicado: (2018)

Evaluating the efficacy of enzalutamide and the development of resistance in a preclinical mouse model of type-I endometrial carcinoma
por: Koivisto, Christopher S., et al.
Publicado: (2020)

Pancreatic cancer-associated stellate cells: A viable target for reducing immunosuppression in the tumor microenvironment
por: Mace, Thomas A, et al.
Publicado: (2013)

Mental health outcomes of mothers who conceived using fertility treatment
por: Raguz, Nikolett, et al.
Publicado: (2014)

Persistent PR segment change in malignant pericardial disease
por: Ahluwalia, M., et al.
Publicado: (2016)

Murine models for familial pancreatic cancer: Histopathology, latency and drug sensitivity among cancers of Palb2, Brca1 and Brca2 mutant mouse strains
por: Park, Dongju, et al.
Publicado: (2019)

Disorder in Ho(2)Ti(2−x)Zr(x)O(7): pyrochlore to defect fluorite solid solution series
por: Drey, Devon L., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_dbccd1kbh01k1ljfc0uol8rl24