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A cannabidiol aminoquinone derivative activates the PP2A/B55α/HIF pathway and shows protective effects in a murine model of traumatic brain injury

BACKGROUND: Traumatic brain injury (TBI) is characterized by a primary mechanical injury and a secondary injury associated with neuroinflammation, blood–brain barrier (BBB) disruption and neurodegeneration. We have developed a novel cannabidiol aminoquinone derivative, VCE-004.8, which is a dual PPA...

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Detalles Bibliográficos
Autores principales: Navarrete, Carmen, García-Martín, Adela, Correa-Sáez, Alejandro, Prados, María E., Fernández, Francisco, Pineda, Rafael, Mazzone, Massimiliano, Álvarez-Benito, Marina, Calzado, Marco A., Muñoz, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270745/
https://www.ncbi.nlm.nih.gov/pubmed/35810304
http://dx.doi.org/10.1186/s12974-022-02540-9