Synthesis and anti-SARS-CoV-2 activity of deuterated GS-441524 analogs

The COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to spread around the world. GS-441524 is the parent nucleoside of remdesivir which is the first drug approved for the treatment of COVID-19, and demonstrates strong activity against SARS-Cov-2 in vitro...

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Detalles Bibliográficos
Autores principales: Zheng, Wei, Hu, Tianwen, Zhang, Yumin, Wei, Daibao, Xie, Yuanchao, Shen, Jingshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270844/
https://www.ncbi.nlm.nih.gov/pubmed/35844292
http://dx.doi.org/10.1016/j.tetlet.2022.154012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270844/
https://www.ncbi.nlm.nih.gov/pubmed/35844292
http://dx.doi.org/10.1016/j.tetlet.2022.154012

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