Loss of Prm1 leads to defective chromatin protamination, impaired PRM2 processing, reduced sperm motility and subfertility in male mice

One of the key events during spermiogenesis is the hypercondensation of chromatin by substitution of the majority of histones by protamines. In humans and mice, protamine 1 (PRM1/Prm1) and protamine 2 (PRM2/Prm2) are expressed in a species-specific ratio. Using CRISPR-Cas9-mediated gene editing, we...

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Detalles Bibliográficos
Autores principales: Merges, Gina Esther, Meier, Julia, Schneider, Simon, Kruse, Alexander, Fröbius, Andreas Christian, Kirfel, Gregor, Steger, Klaus, Arévalo, Lena, Schorle, Hubert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270976/
https://www.ncbi.nlm.nih.gov/pubmed/35608054
http://dx.doi.org/10.1242/dev.200330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270976/
https://www.ncbi.nlm.nih.gov/pubmed/35608054
http://dx.doi.org/10.1242/dev.200330

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