Activation of the Hepcidin-Ferroportin1 pathway in the brain and astrocytic–neuronal crosstalk to counteract iron dyshomeostasis during aging

During physiological aging, iron accumulates in the brain with a preferential distribution in regions that are more vulnerable to age-dependent neurodegeneration such as the cerebral cortex and hippocampus. In the brain of aged wild-type mice, alteration of the Brain Blood Barrier integrity, togethe...

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Detalles Bibliográficos
Autores principales: Mezzanotte, Mariarosa, Ammirata, Giorgia, Boido, Marina, Stanga, Serena, Roetto, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271044/
https://www.ncbi.nlm.nih.gov/pubmed/35810203
http://dx.doi.org/10.1038/s41598-022-15812-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271044/
https://www.ncbi.nlm.nih.gov/pubmed/35810203
http://dx.doi.org/10.1038/s41598-022-15812-4

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