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Chromatin sequesters pioneer transcription factor Sox2 from exerting force on DNA
Biomolecular condensation constitutes an emerging mechanism for transcriptional regulation. Recent studies suggest that the co-condensation between transcription factors (TFs) and DNA can generate mechanical forces driving genome rearrangements. However, the reported forces generated by protein-DNA...
Autores principales: | Nguyen, Tuan, Li, Sai, Chang, Jeremy T-H, Watters, John W., Ng, Htet, Osunsade, Adewola, David, Yael, Liu, Shixin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271091/ https://www.ncbi.nlm.nih.gov/pubmed/35810158 http://dx.doi.org/10.1038/s41467-022-31738-x |
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